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High blood pressure, known medically as hypertension, is one of the most common health problems in modern societies. According to estimates, a million people in Germany suffer from this disease, often without knowing it. Because high blood pressure in the majority of cases, first of all, no clear symptoms, however, may cause long-term serious consequences such as heart attack, stroke or kidney damage. What is the recommended drug treatment? A reduction in blood pressure by means of medicines will be pulled in, as a rule, be considered if the blood pressure is over a longer period of time than the normal value — so a systolic of 140 mmHg or more and/or a diastolic value of 90 mmHg or more. First of all, the doctor tries, however, to lower blood pressure through lifestyle-related measures: a healthy diet with reduced salt consumption, regular physical activity, Weight loss if you are Overweight, Waiver of nicotine and moderate use of alcohol, Stress reduction. These measures are not sufficient alone, a drug therapy to the game. What medications are used? There are different groups of active substances used for the treatment of high blood pressure. The most important are: ACE inhibitors (e.g., Enalapril, Ramipril): they inhibit an enzyme that leads to the formation of a blood vascular engers (Angiotensin II), and thus cause the blood vessels to relax. AT1‑receptor blockers (such as Losartan, Valsartan): they block the action of Angiotensin II directly to the receptors and lead to vascular relaxation. Calcium channel blockers (e.g., amlodipine, nifedipine): prevent the entry of calcium into the muscle cells of the blood vessel walls, which leads to a relaxing and widening the blood vessels. Diuretics (water pills such as hydrochlorothiazide): they promote the excretion of water and salt through the kidneys, reducing the blood volume decreases and blood pressure drops. Beta-blockers (e.g., Metoprolol, Bisoprolol): they lower blood pressure by inhibiting the effect of stress hormones on the heart — the heart beats more slowly and with less force. Often two or more of these active ingredients are combined in order to achieve an optimal reduction in blood pressure. Individual therapy is not a panacea There is no single best drug against high blood pressure. The choice of the right substance or combination depends on many factors: age of the patient, concomitant diseases (such as Diabetes, kidney disease), possible side effects, and individual response to the medication. In addition, the long-term intake of high blood pressure is always associated with regular checks. The doctor checks the blood pressure, examined some of the possible side effects and adjust the dose if necessary. Conclusion Medicines for high blood pressure are an important tool for the prevention of heart and vascular diseases. They work effectively, however, are best used in combination with a healthy lifestyle. The individual adjustment of the therapy by the attending physician is the key to success. Early diagnosis and consistent treatment can improve the quality of life and expectancy significantly.